Nabil G Seidah Selected Research

Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)

1/2020	Functional analysis of natural PCSK9 mutants in modern and archaic humans.
11/2018	Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.
1/2017	The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.
1/2017	The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.
1/2017	Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.
1/2017	Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224.
12/2016	Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015).
11/2015	Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.
1/2015	Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
1/2013	PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.

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Nabil G Seidah Research Topics

Disease

21	Neoplasms (Cancer) 12/2022 - 06/2002
21	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2021 - 06/2003
14	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 10/2004
14	Atherosclerosis 01/2019 - 02/2004
13	Infections 01/2022 - 11/2003
12	Neoplasm Metastasis (Metastasis) 12/2022 - 06/2002
12	Hypercholesterolemia 01/2021 - 10/2006
9	Virus Diseases (Viral Diseases) 12/2022 - 01/2005
8	Inflammation (Inflammations) 12/2022 - 02/2010
7	Insulin Resistance 01/2021 - 08/2013
6	Carcinoma (Carcinomatosis) 01/2008 - 04/2003
5	Melanoma (Melanoma, Malignant) 01/2021 - 12/2010
5	Hepatocellular Carcinoma (Hepatoma) 01/2017 - 06/2013
4	Septic Shock (Toxic Shock Syndrome) 12/2022 - 04/2012
4	Coronary Disease (Coronary Heart Disease) 01/2018 - 06/2003
4	Dyslipidemias (Dyslipidemia) 12/2016 - 07/2007
4	Carcinogenesis 12/2012 - 04/2003
4	Alzheimer Disease (Alzheimer's Disease) 01/2011 - 12/2004
4	Vascular Remodeling 10/2004 - 03/2003
3	Dengue (Dengue Fever) 12/2022 - 10/2020
3	COVID-19 01/2022 - 01/2021
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2020 - 03/2012
3	Fatty Liver 01/2019 - 11/2007
3	Sepsis (Septicemia) 07/2018 - 12/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2013 - 10/2006
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2021 - 01/2021
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 01/2017
2	Colorectal Neoplasms (Colorectal Cancer) 12/2019 - 01/2008
2	Neuroinflammatory Diseases 10/2019 - 11/2015
2	Neurocognitive Disorders (Clerambault Syndrome) 10/2019 - 11/2015
2	Fragile X Syndrome (Martin Bell Syndrome) 10/2019 - 01/2017
2	Neuroblastoma 10/2019 - 03/2003
2	Vascular Calcification 02/2016 - 01/2013
2	Weight Loss (Weight Reduction) 01/2013 - 03/2012
2	Ischemic Stroke 11/2012 - 07/2011
2	Brain Neoplasms (Brain Tumor) 10/2012 - 12/2010
2	Hypertrophy 04/2011 - 01/2011
2	Infertility (Sterility) 10/2008 - 10/2006
2	Human Influenza (Influenza) 10/2008 - 07/2008
2	Communicable Diseases (Infectious Diseases) 10/2008 - 10/2006
2	Atherosclerotic Plaque (Atheroma) 05/2005 - 02/2004
1	Aortic Valve Stenosis (Aortic Stenosis) 01/2022

Drug/Important Bio-Agent (IBA)

33	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 01/2020 - 06/2002
22	FurinIBA 01/2022 - 03/2003
21	LDL Receptors (LDL Receptor)IBA 10/2020 - 06/2003
17	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
16	LDL CholesterolIBA 01/2021 - 06/2003
14	Proprotein Convertase 9IBA 01/2021 - 06/2003
14	CholesterolIBA 01/2021 - 01/2007
12	SubtilisinIBA 11/2018 - 04/2005
11	oxidized low density lipoproteinIBA 01/2019 - 01/2010
11	tetrapeptide carbamateIBA 01/2015 - 03/2003
9	LipidsIBA 12/2019 - 10/2006
6	LDL Lipoproteins (beta Lipoproteins)IBA 01/2017 - 10/2009
5	Monoclonal AntibodiesIBA 12/2022 - 05/2015
5	Small Interfering RNA (siRNA)IBA 12/2022 - 01/2008
5	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 08/2008
5	Messenger RNA (mRNA)IBA 04/2021 - 03/2003
5	Insulin (Novolin)FDA Link 01/2021 - 05/2005
5	Antiviral Agents (Antivirals)IBA 01/2021 - 08/2005
5	CytokinesIBA 10/2019 - 04/2012
5	ApolipoproteinsIBA 04/2015 - 06/2003
4	Lipoprotein(a)IBA 01/2022 - 05/2015
4	PCSK9 InhibitorsIBA 01/2021 - 01/2013
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2010
4	Peptides (Polypeptides)IBA 01/2020 - 03/2003
4	EnzymesIBA 10/2008 - 09/2004
3	Biological ProductsIBA 12/2022 - 05/2005
3	HDL CholesterolIBA 10/2021 - 10/2009
3	Apolipoproteins B (ApoB)IBA 01/2021 - 06/2003
3	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2021 - 03/2002
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2020 - 08/2004
3	Triglycerides (Triacylglycerol)IBA 12/2019 - 04/2011
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 04/2004
3	Amyloid (Amyloid Fibrils)IBA 01/2011 - 06/2002
3	Amyloid beta-PeptidesIBA 02/2010 - 12/2004
3	Matrix Metalloproteinase 14 (MT1-MMP)IBA 05/2005 - 08/2004
3	IntegrinsIBA 04/2005 - 02/2004
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 12/2022 - 10/2021
2	VaccinesIBA 01/2021 - 01/2013
2	LipopolysaccharidesIBA 07/2018 - 04/2012
2	SterolsIBA 01/2017 - 10/2006
2	Chelating AgentsIBA 03/2016 - 06/2013
2	IronIBA 03/2016 - 06/2013
2	InterleukinsIBA 02/2016 - 11/2015
2	Biomarkers (Surrogate Marker)IBA 12/2015 - 03/2012
2	LigandsIBA 12/2013 - 10/2009
2	Cadherins (E-Cadherin)IBA 10/2012 - 12/2010
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2009 - 12/2004
2	Vascular Endothelial Growth Factor CIBA 05/2005 - 06/2003
2	Integrin alphaVIBA 02/2004 - 03/2003
2	protease SIBA 06/2003 - 04/2003
1	camostatIBA 01/2022
1	Serine Proteases (Serine Protease)IBA 01/2022
1	Caffeine (No Doz)FDA LinkGeneric 01/2022
1	Angiotensin-Converting Enzyme 2IBA 01/2022
1	Protein SIBA 01/2022

Therapy/Procedure

7	Therapeutics 01/2021 - 06/2002
3	Injections 12/2022 - 01/2021
2	Immunotherapy 12/2022 - 10/2021